Drug-Induced Psychoses May Signal Substantial Schizophrenia Risk

More than a third of people who experienced psychosis with cannabis use later transitioned to schizophrenia, according to a systematic review and meta-analysis published online in Schizophrenia Bulletin. Similarly, schizophrenia transition risk among people who experienced psychosis from hallucinogen or amphetamine use was also considerable.

Transition to schizophrenia was highest (34%) for cannabis-induced psychoses

Overall 25% of people with substance-induced psychosis were later diagnosed with schizophrenia, compared with 36% of people who first presented with brief, atypical, and not otherwise specified psychoses. Among the 25 studies that looked at substance use-induced psychosis, transition to schizophrenia was highest (34%) for cannabis-induced psychoses.

Substance-Induced Psychosis Associated With Increased Risk of Schizophrenia, Meta-Analysis Finds

People who experience psychosis following the use of cannabis, hallucinogens, or amphetamines (known as substance-induced psychosis) may be at a greater risk of developing schizophrenia, according to a meta-analysis in Schizophrenia Bulletin. This risk was found to be only slightly less than that observed for patients who presented with other brief psychotic disorders.